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Review
. 2012 Aug;10(8):935-46.
doi: 10.1586/eri.12.74.

Candida parapsilosis and the neonate: epidemiology, virulence and host defense in a unique patient setting

Brian D W Chow  1 , Jennifer R Linden, Joseph M Bliss
Affiliations
Review

Candida parapsilosis and the neonate: epidemiology, virulence and host defense in a unique patient setting

Brian D W Chow et al. Expert Rev Anti Infect Ther. 2012 Aug.

Abstract

Invasive candidiasis is a common problem in premature infants that leads to high morbidity and mortality. Although Candida albicans has historically been the most prominent species involved in these infections and has therefore been the subject of the most study, Candida parapsilosis is increasing in frequency, and neonates are disproportionately affected. This article reviews unique aspects of the epidemiology of this organism as well as strategies for prophylaxis against invasive candidiasis in general. Additionally, important differences between C. parapsilosis and C. albicans are coming to light related to virulence determinants and interactions with components of host immunity. These developments are reviewed while highlighting the significant gaps in our understanding that remain to be elucidated.

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Figures

Figure 1
Figure 1. Distribution of Candida species by age
ICU: Intensive care unit. Data taken from [1,21].
Figure 2
Figure 2. Immune response to Candida parapsilosis.
Factors involved in (A) immune evasion and (B) epithelial colonization and damage by Candida parapsilosis. See text for further details. Lip: Lipase; SAP: Secreted aspartyl protease.
See this image and copyright information in PMC

References

    1. Benjamin DK, Jr, Stoll BJ, Fanaroff AA, et al. National Institute of Child Health and Human Development Neonatal Research Network. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006;117(1):84–92. Provided neurodevelopmetal follow-up of a large cohort of infants of <1000 g birthweight with invasive candidiasis and demonstrated very high rates of death or neurodevelopmental impairment. Also demonstrated higher mortality risk with delayed removal or replacement of central venous catheters. - PubMed
    1. Trofa D, Gácser A, Nosanchuk JD. Candida parapsilosis, an emerging fungal pathogen. Clin Microbiol Rev. 2008;21(4):606–625. - PMC - PubMed
    1. van Asbeck EC, Clemons KV, Stevens DA. Candida parapsilosis: a review of its epidemiology, pathogenesis, clinical aspects, typing and antimicrobial susceptibility. Crit Rev Microbiol. 2009;35(4):283–309. - PubMed
    1. Tavanti A, Davidson AD, Gow NA, Maiden MC, Odds FC. Candida orthopsilosis and Candida metapsilosis spp. nov to replace Candida parapsilosis groups II and III. J Clin Microbiol. 2005;43(1):284–292. - PMC - PubMed
    1. Gomez-Lopez A, Alastruey-Izquierdo A, Rodriguez D, et al. Barcelona Candidemia Project Study Group. Prevalence and susceptibility profile of Candida metapsilosis and Candida orthopsilosis: results from population-based surveillance of candidemia in Spain. Antimicrob Agents Chemother. 2008;52(4):1506–1509. - PMC - PubMed

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