Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Oct;14(10):694-700.
doi: 10.1111/j.1751-7176.2012.00690.x. Epub 2012 Aug 3.

Prevalence and correlates of low medication adherence in apparent treatment-resistant hypertension

Marguerite R Irvin  1 , Daichi Shimbo, Devin M Mann, Kristi Reynolds, Marie Krousel-Wood, Nita A Limdi, Daniel T Lackland, David A Calhoun, Suzanne Oparil, Paul Muntner
Affiliations

Prevalence and correlates of low medication adherence in apparent treatment-resistant hypertension

Marguerite R Irvin et al. J Clin Hypertens (Greenwich). 2012 Oct.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] J Clin Hypertens (Greenwich). 2018 Jun;20(6):1080. doi: 10.1111/jch.13317. Epub 2018 May 25. J Clin Hypertens (Greenwich). 2018. PMID: 29902366 Free PMC article. No abstract available.

Abstract

Low medication adherence may explain part of the high prevalence of apparent treatment-resistant hypertension (aTRH). The authors assessed medication adherence and aTRH among 4026 participants taking ≥ 3 classes of antihypertensive medication in the population-based Reasons for Geographic and Racial Differences in Stroke (REGARDS) trial using the 4-item Morisky Medication Adherence Scale (MMAS). Low adherence was defined as an MMAS score ≥ 2. Overall, 66% of participants taking ≥ 3 classes of antihypertensive medication had aTRH. Perfect adherence on the MMAS was reported by 67.8% and 70.9% of participants with and without aTRH, respectively. Low adherence was present among 8.1% of participants with aTRH and 5.0% of those without aTRH (P<.001). Among those with aTRH, female sex, residence outside the US stroke belt or stroke buckle, physical inactivity, elevated depressive symptoms, and a history of coronary heart disease were associated with low adherence. In the current study, a small percentage of participants with aTRH had low adherence.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Hypertension control rates associated with level of medication adherence among Reasons for Geographic and Racial Differences in Stroke (REGARDS) study participants taking at least 3 antihypertensive medication classes.
Figure 2
Figure 2
Level of adherence among Reasons for Geographic and Racial Differences in Stroke (REGARDS) study participants by apparent treatment‐resistant hypertension status. P<.001 comparing the distribution of Morisky Medication Adherence Scale scores.
See this image and copyright information in PMC

References

    1. Calhoun DA, Jones D, Textor S, et al. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation. 2008;117:e510–e526. - PubMed
    1. Egan BM, Zhao Y, Axon RN, et al. Uncontrolled and apparent treatment resistant hypertension in the United States, 1988 to 2008. Circulation. 2011;124:1046–1058. - PMC - PubMed
    1. Elliott WJ. Improving outcomes in hypertensive patients: focus on adherence and persistence with antihypertensive therapy. J Clin Hypertens (Greenwich). 2009;11:376–382. - PMC - PubMed
    1. Mazzaglia G, Mantovani LG, Sturkenboom MC, et al. Patterns of persistence with antihypertensive medications in newly diagnosed hypertensive patients in Italy: a retrospective cohort study in primary care. J Hypertens. 2005;23:2093–2100. - PubMed
    1. Van Wijk BL, Klungel OH, Heerdink ER, de Boer A. Rate and determinants of 10‐year persistence with antihypertensive drugs. J Hypertens. 2005;23:2101–2107. - PubMed

Publication types

Substances