doi: 10.1007/BF00200569.
Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients
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- PMID: 2303247
- DOI: 10.1007/BF00200569
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Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients
Hum Genet.
1990 Feb.
Abstract
The frequency of spontaneous 6-thioguanine (TG)-resistant peripheral blood lymphocytes in five unrelated Werner syndrome (WS) patients was determined using an autoradiographic labeling assay. The average frequency of TG-resistant lymphocytes was eightfold higher in WS patients than in sex- and age-matched normal control donors. This finding and previous identification of increased spontaneous chromosomal rearrangements and deletions in WS cells or cell lines suggest that WS is a human genomic instability or mutator syndrome.
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