Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Feb;84(3):249-52.
doi: 10.1007/BF00200569.

Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients

K Fukuchi  1 , K Tanaka, Y Kumahara, K Marumo, M B Pride, G M Martin, R J Monnat Jr
Affiliations

Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients

K Fukuchi et al. Hum Genet. 1990 Feb.

Abstract

The frequency of spontaneous 6-thioguanine (TG)-resistant peripheral blood lymphocytes in five unrelated Werner syndrome (WS) patients was determined using an autoradiographic labeling assay. The average frequency of TG-resistant lymphocytes was eightfold higher in WS patients than in sex- and age-matched normal control donors. This finding and previous identification of increased spontaneous chromosomal rearrangements and deletions in WS cells or cell lines suggest that WS is a human genomic instability or mutator syndrome.

PubMed Disclaimer

References

    1. Mutagenesis. 1987 Sep;2(5):341-7 - PubMed
    1. Environ Mutagen. 1985;7 Suppl 4:31-41 - PubMed
    1. Hum Genet. 1983;64(3):288-90 - PubMed
    1. Leukemia. 1988 Apr;2(4):199-208 - PubMed
    1. Nature. 1974 Apr 26;248(5451):762-3 - PubMed

Publication types

LinkOut - more resources