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. 2012 Oct 1;176 Suppl 7(Suppl 7):S99-105.
doi: 10.1093/aje/kws298.

Low birth weight is associated with higher blood pressure variability from childhood to young adulthood: the Bogalusa Heart Study

Wei Chen  1 , Sathanur R Srinivasan, Lu Yao, Shengxu Li, Pronabesh Dasmahapatra, Camilo Fernandez, Jihua Xu, Gerald S Berenson
Affiliations

Low birth weight is associated with higher blood pressure variability from childhood to young adulthood: the Bogalusa Heart Study

Wei Chen et al. Am J Epidemiol. .

Abstract

The association between birth weight and long-term within-individual variability of blood pressure (BP) was examined in a longitudinal cohort of 1,454 adults (939 whites and 515 blacks; adulthood age = 19-50 years) enrolled in the Bogalusa Heart Study in Bogalusa, Louisiana, in 1973-2010. BP variability was depicted as standard deviation, coefficient of variation, and deviation from age-predicted values using 6-15 serial BP measurements from childhood to adulthood over an average of 25.7 years. Birth weight was significantly and negatively associated with adulthood BP levels, long-term BP levels, and rate of change. Importantly, low birth weight was significantly associated with increased BP variability in terms of standard deviation, coefficient of variation, and deviation. As evaluated using the regression coefficients, a 1-kg lower birth weight was associated with increases in systolic BP variability measures (-0.38 mm Hg, P = 0.04 for standard deviation; -0.004 mm Hg, P = 0.01 for coefficient of variation; and -0.16 mm Hg, P = 0.04 for deviation) after adjustment for race, age, sex, mean BP levels, and gestational age; similar trends in the associations were noted for diastolic BP variability measures. In conclusion, these findings suggest that birth weight affects not only BP levels but also the magnitude of within-individual BP fluctuations over time through fetal programming in BP regulation mechanisms.

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Figures

Figure 1.
Figure 1.
The area under the curve (AUC) of systolic blood pressure (BP) and 2 examples (individuals 1 and 2), Bogalusa Heart Study, Bogalusa, Louisiana, 1973–2010. Fixed parameters of the overall growth curve (top panel): SBP = 113 + (0.89 × age) – (0.54 × age2) + (0.08 × age3); random effects incorporated for individual 1 (middle panel): SBP = 100 + (1.7 × age) – (0.63 × age2) + (0.12 × age3); and random effects incorporated for individual 2 (bottom panel): SBP =110 + (0.61 × age) – (0.41 × age2) + (0.06 × age3). a, incremental AUC; b, baseline AUC.
Figure 2.
Figure 2.
Deviation from age-predicted values of systolic blood pressure (BP) of individual 2, Bogalusa Heart Study, Bogalusa, Louisiana, 1973–2010.
See this image and copyright information in PMC

References

    1. Mancia G, Parati G. The role of blood pressure variability in end-organ damage. J Hypertens Suppl. 2003;21(6):S17–S23. - PubMed
    1. Rothwell PM. Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension. Lancet. 2010;375(9718):938–948. - PubMed
    1. Rothwell PM, Howard SC, Dolan E, et al. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet. 2010;375(9718):895–905. - PubMed
    1. Webb AJ, Fischer U, Mehta Z, et al. Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis. Lancet. 2010;375(9718):906–915. - PubMed
    1. Havlik RJ, Foley DJ, Sayer B, et al. Variability in midlife systolic blood pressure is related to late-life brain white matter lesions: the Honolulu-Asia Aging study. Stroke. 2002;33(1):26–30. - PubMed

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