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Comment

. 2012 Oct;87(10):1032-3; author reply 1033.

doi: 10.1016/j.mayocp.2012.07.012.

Polyclonal immunoglobulin free light chain and chronic inflammation

Frank A Redegeld, Marco Thio, Tom Groot Kormelink

PMID: 23036675
PMCID: PMC3497911
DOI: 10.1016/j.mayocp.2012.07.012

Comment

Polyclonal immunoglobulin free light chain and chronic inflammation

Frank A Redegeld et al. Mayo Clin Proc. 2012 Oct.

. 2012 Oct;87(10):1032-3; author reply 1033.

doi: 10.1016/j.mayocp.2012.07.012.

Authors

Frank A Redegeld, Marco Thio, Tom Groot Kormelink

PMID: 23036675
PMCID: PMC3497911
DOI: 10.1016/j.mayocp.2012.07.012

No abstract available

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Figures

FIGURE
Immune disorders associated with increased immunoglobulin free light chains (FLC) and effector functions of immunoglobulin FLC leading inflammatory diseases via mast cell and neutrophil activation. COPD = chronic obstructive pulmonary disease; IBD = inflammatory bowel disease; IPF = idiopathic pulmonary fibrosis; RA = rheumatoid arthritis.

See this image and copyright information in PMC

Comment on

Use of nonclonal serum immunoglobulin free light chains to predict overall survival in the general population.
Dispenzieri A, Katzmann JA, Kyle RA, Larson DR, Therneau TM, Colby CL, Clark RJ, Mead GP, Kumar S, Melton LJ 3rd, Rajkumar SV. Dispenzieri A, et al. Mayo Clin Proc. 2012 Jun;87(6):517-23. doi: 10.1016/j.mayocp.2012.03.009. Mayo Clin Proc. 2012. PMID: 22677072 Free PMC article.

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References

1. Dispenzieri A., Katzmann J.A., Kyle R.A. Use of nonclonal serum immunoglobulin free light chains to predict overall survival in the general population. Mayo Clin Proc. 2012;87(6):517–523. - PMC - PubMed
1. Drayson M.T. Using single protein biomarkers to predict health and disease in diverse patient populations: a new role for assessment of immunoglobulin free light chains [editorial] Mayo Clin Proc. 2012;87(6):505–507. - PMC - PubMed
1. Thio M., Blokhuis B.R., Nijkamp F.P., Redegeld F.A. Free immunoglobulin light chains: a novel target in the therapy of inflammatory diseases. Trends Pharmacol Sci. 2008;29(4):170–174. - PubMed
1. Redegeld F.A., van der Heijden M.W., Kool M. Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses. Nat Med. 2002;8(7):694–701. - PubMed
1. Braber S., Thio M., Blokhuis B.R. An association between neutrophils and immunoglobulin free light chains in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;185(8):817–824. - PubMed

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