Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Oct;87(10):1032-3; author reply 1033.
doi: 10.1016/j.mayocp.2012.07.012.

Polyclonal immunoglobulin free light chain and chronic inflammation

Frank A Redegeld, Marco Thio, Tom Groot Kormelink
Comment

Polyclonal immunoglobulin free light chain and chronic inflammation

Frank A Redegeld et al. Mayo Clin Proc. 2012 Oct.
No abstract available

PubMed Disclaimer

Figures

FIGURE
FIGURE
Immune disorders associated with increased immunoglobulin free light chains (FLC) and effector functions of immunoglobulin FLC leading inflammatory diseases via mast cell and neutrophil activation. COPD = chronic obstructive pulmonary disease; IBD = inflammatory bowel disease; IPF = idiopathic pulmonary fibrosis; RA = rheumatoid arthritis.
See this image and copyright information in PMC

Comment on

References

    1. Dispenzieri A., Katzmann J.A., Kyle R.A. Use of nonclonal serum immunoglobulin free light chains to predict overall survival in the general population. Mayo Clin Proc. 2012;87(6):517–523. - PMC - PubMed
    1. Drayson M.T. Using single protein biomarkers to predict health and disease in diverse patient populations: a new role for assessment of immunoglobulin free light chains [editorial] Mayo Clin Proc. 2012;87(6):505–507. - PMC - PubMed
    1. Thio M., Blokhuis B.R., Nijkamp F.P., Redegeld F.A. Free immunoglobulin light chains: a novel target in the therapy of inflammatory diseases. Trends Pharmacol Sci. 2008;29(4):170–174. - PubMed
    1. Redegeld F.A., van der Heijden M.W., Kool M. Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses. Nat Med. 2002;8(7):694–701. - PubMed
    1. Braber S., Thio M., Blokhuis B.R. An association between neutrophils and immunoglobulin free light chains in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;185(8):817–824. - PubMed

Substances