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. 2012 Nov 15;22(22):6980-5.
doi: 10.1016/j.bmcl.2012.06.002. Epub 2012 Aug 30.

N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT₆ receptor antagonists

Ramakrishna V S Nirogi  1 , Jagadishu Babu Konda, Ramasastry Kambhampati, Anil Shinde, Thrinath Reddy Bandyala, Parandhama Gudla, Kiran Kumar Kandukuri, Pradeep Jayarajan, Vishwottam Kandikere, P K Dubey
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N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT₆ receptor antagonists

Ramakrishna V S Nirogi et al. Bioorg Med Chem Lett. .

Abstract

The design, synthesis and SAR of novel tetrahydrocarbazole derivatives having 5-HT(6) receptor antagonist activity is presented. The racemic compound 15e was found to possess desirable pharmacokinetic properties, adequate brain penetration and activity in animal models of cognition.

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