Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2012;61(2):135-41.
doi: 10.1159/000342084.

Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adults

Steven K Malin  1 , Nicole Niemi, Thomas P J Solomon, Jacob M Haus, Karen R Kelly, Julianne Filion, Michael Rocco, Sangeeta R Kashyap, Hope Barkoukis, John P Kirwan
Affiliations
Randomized Controlled Trial

Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adults

Steven K Malin et al. Ann Nutr Metab. 2012.

Abstract

Background: The efficacy of combining carbohydrate quality with exercise on metabolic syndrome risk is unclear. Thus, we determined the effects of exercise training with a low (LoGIx)- or high (HiGIx)-glycemic index diet on the severity of the metabolic syndrome (Z-score).

Methods: Twenty-one adults (66.2±1.1 years; BMI=35.3±0.9 kg/m2) with the metabolic syndrome were randomized to 12 weeks of exercise (60 min/day for 5 days/week at about 85% HRmax) and provided a LoGIx (n=11) or HiGIx (n=10) diet. Z-scores were determined from: blood pressure, triglycerides (TGs), high-density lipoproteins (HDLs), fasting plasma glucose (FPG), and waist circumference (WC) before and after the intervention. Body composition, aerobic fitness, insulin resistance, and nonesterfied fatty acid (NEFA) suppression were also assessed.

Results: LoGIx and HiGIx diets decreased body mass and insulin resistance and increased aerobic fitness comparably (p<0.05). LoGIx and HiGIx diets decreased the Z-score similarly as each intervention decreased blood pressure, TGs, FPG and WC (p<0.05). The HiGIx diet tended to suppress NEFA during insulin stimulation compared with the LoGIx diet (p=0.06).

Conclusions: Our findings highlight that exercise with weight loss reduces the severity of the metabolic syndrome whether individuals were randomized to a HiGIx or a LoGIx diet.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflict of interest.

Figures

Figure 1
Figure 1
Figure 1a. Effects of HiGIx and LoGIx on metabolic syndrome Z-score outcomes. Data are mean ± standard error of mean. ^LoGIx compared to HiGIx (group x test interaction; p <0.05). *Test effect (p < 0.05). Figure 1b. Effects of HiGIx and LoGIx on metabolic syndrome criteria. Data are mean ± standard error of mean. ^LoGIx compared to HiGIx (group x test interaction; p <0.05).*Test effect (p < 0.05).
Figure 1
Figure 1
Figure 1a. Effects of HiGIx and LoGIx on metabolic syndrome Z-score outcomes. Data are mean ± standard error of mean. ^LoGIx compared to HiGIx (group x test interaction; p <0.05). *Test effect (p < 0.05). Figure 1b. Effects of HiGIx and LoGIx on metabolic syndrome criteria. Data are mean ± standard error of mean. ^LoGIx compared to HiGIx (group x test interaction; p <0.05).*Test effect (p < 0.05).
See this image and copyright information in PMC

References

    1. Ford E, Giles W, Dietz W. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002;287(3):356–359. - PubMed
    1. Orchard TJ, Temprosa M, Goldberg R, Haffner S, Ratner R, Marcovina S, Fowler S Diabetes Prevention Program Research Group. The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial. Ann Intern Med. 2005;142(8):611–619. - PMC - PubMed
    1. Katzmarzyk P, Leon A, Wilmore J, Skinner J, Rao DC, Rankinen T, Bouchard C. Targeting the metabolic syndrome with exercise: evidence from the HERITAGE Family Study. Med Sci Sports Exerc. 2003;35(10):1703–1709. - PubMed
    1. Villareal D, Miller B, Banks M, Fontana L, Sinacore D, Klein S. Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Am J Clin Nutr. 2006;84(6):1317–1323. - PubMed
    1. Stewart K, Bacher A, Turner K, Lim J, Hees P, Shapiro E, Tayback M, Ouyang P. Exercise and risk factors associated with metabolic syndrome in older adults. Am J Prev Med. 2005;28(1):9–18. - PubMed

Publication types

MeSH terms