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Comment
. 2012 Oct;19(10):973-5.
doi: 10.1038/nsmb.2401.

Context is everything: activators can also repress

Richard Festenstein  1 , Jackson P K Chan
Affiliations
Comment

Context is everything: activators can also repress

Richard Festenstein et al. Nat Struct Mol Biol. 2012 Oct.

Abstract

Maintenance of genome integrity, cell division and gene expression have all been shown to be regulated by the condensation of DNA into heterochromatin. In a study published in this issue, Bulut-Karslioglu et al. reveal a new heterochromatin function for transcription factors in a mammalian system. They show that instead of activating gene expression, in the context of heterochromatic repeats, specific transcription factors are necessary for the maintenance of transcriptional repression and heterochromatin.

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Comment on

  • A transcription factor-based mechanism for mouse heterochromatin formation.
    Bulut-Karslioglu A, Perrera V, Scaranaro M, de la Rosa-Velazquez IA, van de Nobelen S, Shukeir N, Popow J, Gerle B, Opravil S, Pagani M, Meidhof S, Brabletz T, Manke T, Lachner M, Jenuwein T. Bulut-Karslioglu A, et al. Nat Struct Mol Biol. 2012 Oct;19(10):1023-30. doi: 10.1038/nsmb.2382. Epub 2012 Sep 16. Nat Struct Mol Biol. 2012. PMID: 22983563

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