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. 2012 Summer;24(3):309-15.
doi: 10.1176/appi.neuropsych.11080188.

Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury

Vani Rao  1 , Michelle Mielke, Xin Xu, Gwenn S Smith, Una D McCann, Alyssa Bergey, Vishal Doshi, Dzung L Pham, David Yousem, Susumi Mori
Affiliations

Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury

Vani Rao et al. J Neuropsychiatry Clin Neurosci. 2012 Summer.

Abstract

There are currently no known early neuroanatomical markers predictive of the development of major depression or depressive symptoms after mild traumatic brain injury (mTBI). The authors conducted a 1-year longitudinal pilot study to determine whether diffusion tensor imaging (DTI) measures collected within 1 month of mTBI could predict incident depression. Of the 14 subjects who met study inclusion criteria, 4 (28.6%) developed major depression over the follow-up period. Compared with the nondepressed group, those who developed depression had white-matter abnormalities in the fronto-temporal regions measured by DTI. These preliminary results highlight the need for additional studies, including studies using a larger sample and appropriate controls.

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References

    1. Jorge RE, Robinson RG, Moser D, et al. Major depression following traumatic brain injury. Arch Gen Psychiatry. 2004;61:42–50. - PubMed
    1. Levin HS, Brown SA, Song JX, et al. Depression and post-traumatic stress disorder at three months after mild-to-moderate traumatic brain injury. J Clin Exp Neuropsychol. 2001;23:754–769. - PubMed
    1. Rao V, Bertrand M, Rosenberg P, et al. Predictors of new-onset depression after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2010;22:100–104. - PMC - PubMed
    1. Povlishock JT. Traumatically-induced axonal injury: pathogenesis and pathobiological implications. Brain Pathol. 1992;2:1–12. - PubMed
    1. Signoretti S, Vagnozzi R, Tavazzi B, et al. Biochemical and neurochemical sequelae following mild traumatic brain injury: summary of experimental data and clinical implications. Neurosurg Focus. 2010;29:E1. - PubMed

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