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. 1990 Jan;53(1):33-8.
doi: 10.1136/jnnp.53.1.33.

Measurements of regional cerebral blood flow and cognitive performance in Alzheimer's disease

D Montaldi  1 , D N Brooks, J H McColl, D Wyper, J Patterson, E Barron, J McCulloch
Affiliations

Measurements of regional cerebral blood flow and cognitive performance in Alzheimer's disease

D Montaldi et al. J Neurol Neurosurg Psychiatry. 1990 Jan.

Abstract

Single photon emission computed tomography (SPECT) with 99mTc-HMPAO was used to image 26 patients with dementia of the Alzheimer type (DAT) and 10 healthy controls. Regional cerebral blood flow (rCBF) data indicated a relative sparing of the occipital regions in DAT. Normalisation to occipital flow illustrated highly significant CBF deficits in a number of cortical regions, particularly in the left and right posterior--temporal cortex in DAT compared to controls. The cognitive performance of DAT patients was measured using a clinical cognitive assessment procedure (CAMCOG) and numerous correlations between these scores and rCBF were obtained. The implications and value of this investigative technique are discussed.

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References

    1. J Psychiatr Res. 1975 Nov;12(3):189-98 - PubMed
    1. Br J Psychiatry. 1964 Jan;110:80-3 - PubMed
    1. Ann Neurol. 1983 Nov;14(5):497-506 - PubMed
    1. Neurology. 1985 Feb;35(2):235-7 - PubMed
    1. Ann Neurol. 1984 Dec;16(6):649-54 - PubMed

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