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. 2012 Oct 29;51(44):11166-9.
doi: 10.1002/anie.201206489. Epub 2012 Oct 4.

An RNA-deaminase conjugate selectively repairs point mutations

Thorsten Stafforst  1 , Marius F Schneider
Affiliations

An RNA-deaminase conjugate selectively repairs point mutations

Thorsten Stafforst et al. Angew Chem Int Ed Engl. .

Abstract

Checking for mistakes: By conjugating a catalytic domain with a guide RNA, deamination activity can be harnessed to repair a specific codon on mRNA. This method can be used for the highly selective repair of point mutations in mRNA by site-selective editing.

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