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Comment
. 2012 Oct 3;16(4):411-3.
doi: 10.1016/j.cmet.2012.09.011.

Fate through fat: lipid metabolism determines stem cell division outcome

Rushdia Zareen Yusuf  1 , David T Scadden
Affiliations
Comment

Fate through fat: lipid metabolism determines stem cell division outcome

Rushdia Zareen Yusuf et al. Cell Metab. .

Abstract

Distinctive metabolism associated with particular cell states is increasingly being defined in normal and malignant cells. Ito et al. (2012) now show that fatty acid oxidation is associated with hematopoietic stem cells and determines whether they undergo symmetric or asymmetric cell division, driving a fundamental property of the stem cell state.

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Figures

Figure 1
Figure 1. Fatty Acid Oxidation Maintains Asymmetric HSC Division
(A) The promyelocytic (PML) gene regulates PPARδ to increase fatty acid oxidation (FAO) in hematopoietic stem cells (HSCs) and biases them toward the fate of asymmetric cell division, leading to continued maintenance of the HSC pool. (B) Potential mechanisms by which FAO maintains asymmetric self renewal include (1) shunting of long chain fatty acids away from lipid and cell membrane synthesis, which is not a major requirement for the slowly self renewing HSCs; (2) generation of ATP for HSC energy needs; (3) generation of reducing equivalents for quenching reactive oxygen species (ROS); and (4) generation of acetyl-CoA, chromatin modification, and preservation of the stem cell epigenome.
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Comment on

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