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Comment
. 2012 Oct 5;11(4):447-9.
doi: 10.1016/j.stem.2012.09.008.

Hematopoietic stem cells burn fat to prevent exhaustion

Valerie Lallemand-Breitenbach, Hugues de Thé
Free article
Comment

Hematopoietic stem cells burn fat to prevent exhaustion

Valerie Lallemand-Breitenbach et al. Cell Stem Cell. .
Free article

Abstract

Ito et al. (2012) recently report in Nature Medicine that fatty acid oxidation (FAO) regulated by PPARδ controls asymmetric division in hematopoietic stem cells (HSCs). This metabolic mechanism prevents HSC exhaustion and is downstream of the promyelocytic leukemia protein PML, suggesting therapeutic implications for HSC function and disease.

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