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. 2012 Nov;44(11):1222-6.
doi: 10.1038/ng.2438. Epub 2012 Oct 7.

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population

Tomomitsu Hirota  1 , Atsushi Takahashi, Michiaki Kubo, Tatsuhiko Tsunoda, Kaori Tomita, Masafumi Sakashita, Takechiyo Yamada, Shigeharu Fujieda, Shota Tanaka, Satoru Doi, Akihiko Miyatake, Tadao Enomoto, Chiharu Nishiyama, Nobuhiro Nakano, Keiko Maeda, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda, Emiko Noguchi, Tohru Sakamoto, Nobuyuki Hizawa, Koji Ebe, Hidehisa Saeki, Takashi Sasaki, Tamotsu Ebihara, Masayuki Amagai, Satoshi Takeuchi, Masutaka Furue, Yusuke Nakamura, Mayumi Tamari
Affiliations

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population

Tomomitsu Hirota et al. Nat Genet. 2012 Nov.

Abstract

Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P(combined) = 8.36 × 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 × 10(-20)), OR10A3-NLRP10 (P = 1.54 × 10(-22)), GLB1 (P = 2.77 × 10(-16)), CCDC80 (P = 1.56 × 10(-19)), CARD11 (P = 7.83 × 10(-9)), ZNF365 (P = 5.85 × 10(-20)) and CYP24A1-PFDN4 (P = 1.65 × 10(-8)). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.

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References

    1. Lancet. 2011 Sep 10;378(9795):1006-14 - PubMed
    1. Nature. 2010 Oct 28;467(7319):1061-73 - PubMed
    1. IARC Sci Publ. 1987;(82):1-406 - PubMed
    1. Nat Genet. 2011 Jun 12;43(7):690-4 - PubMed
    1. Genet Epidemiol. 2010 Dec;34(8):816-34 - PubMed

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