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. 2012 Nov;14(6):875-8.
doi: 10.1038/aja.2012.95. Epub 2012 Oct 8.

Testosterone is negatively associated with the severity of coronary atherosclerosis in men

Li Li  1 , Chang-Yan Guo, En-Zhi Jia, Tie-Bing Zhu, Lian-Sheng Wang, Ke-Jiang Cao, Wen-Zhu Ma, Zhi-Jian Yang
Affiliations

Testosterone is negatively associated with the severity of coronary atherosclerosis in men

Li Li et al. Asian J Androl. 2012 Nov.

Abstract

This study aimed to determine whether plasma testosterone is associated with the severity of coronary atherosclerosis in a group of 803 men who underwent elective coronary angiography. Testosterone levels were measured in 803 male patients who were categorized into three groups according to testosterone level tertiles. All patients underwent elective coronary angiography, and the severity of coronary artery disease (CAD) was determined by the Gensini score. Moreover, patients were classified into two groups according to Gensini scores (score ≤26 and score >26) using the median values as cutoff points. The plasma testosterone levels were measured by an ELISA kit. The level of testosterone was negatively associated with the Gensini score (r=-0.188; P=0.000). A multiple linear regression analysis revealed that testosterone was an independent risk factor for the Gensini score (β=-0.110; P=0.002) after adjusting for confounding covariates. In a multivariate logistic regression model, the severity of CAD was shown to be significantly lower in the third tertile (highest) of testosterone compared to the first tertile (lowest) of testosterone (odds ratio (OR)=0.465; 95% confidence interval (CI): 0.327-0.662; P=0.000). In this study, patients with lower testosterone levels had higher Gensini scores in a group of 803 men who underwent elective coronary angiography. Additional studies are needed to clarify the direction of causality and possible underlying mechanisms.

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Figures

Figure 1
Figure 1
Multiple linear regression analysis with testosterone level as independent predictors for gensini score.
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References

    1. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med. 1999;340:1801–11. - PubMed
    1. Jousilahti P, Vartiainen E, Tuomilehto J, Puska P. Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in Finland. Circulation. 1999;99:1165–72. - PubMed
    1. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab. 2001;86:724–31. - PubMed
    1. Phillips GB, Castelli WP, Abbot RD, McNamara PM. Association of hyperestrogenemia and coronary heart disease in men in the Framingham cohort. Am J Med. 1983;74:863–9. - PubMed
    1. English KM, Mandour O, Steeds RP, Diver MJ, Jones TH, et al. Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms. Eur Heart J. 2000;21:890–4. - PubMed

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