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Review
. 2012 Oct 16;109 Suppl 2(Suppl 2):17261-5.
doi: 10.1073/pnas.1121087109. Epub 2012 Oct 8.

Genetic and environmental vulnerabilities in children with neurodevelopmental disorders

Annette Karmiloff-Smith  1 , Dean D'Souza, Tessa M Dekker, Jo Van Herwegen, Fei Xu, Maja Rodic, Daniel Ansari
Affiliations
Review

Genetic and environmental vulnerabilities in children with neurodevelopmental disorders

Annette Karmiloff-Smith et al. Proc Natl Acad Sci U S A. .

Abstract

One might expect that children with varying genetic mutations or children raised in low socioeconomic status environments would display different deficits. Although this expectation may hold for phenotypic outcomes in older children and adults, cross-syndrome comparisons in infancy reveal many common neural and sociocognitive deficits. The challenge is to track dynamic trajectories over developmental time rather than focus on end states like in adult neuropsychological studies. We contrast the developmental and adult approaches with examples from the cognitive and social domains, and we conclude that static models of adult brain lesions cannot be used to account for the dynamics of change in genetic and environmentally induced disorders in children.

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Conflict of interest statement

The authors declare no conflict of interest.

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