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. 2012 Sep-Oct;25(5):397-402.
doi: 10.1111/j.1529-8019.2012.01499.x.

Genetic counseling in melanoma

Celia Badenas  1 , Paula Aguilera, Joan A Puig-Butillé, Cristina Carrera, Josep Malvehy, Susana Puig
Affiliations

Genetic counseling in melanoma

Celia Badenas et al. Dermatol Ther. 2012 Sep-Oct.

Abstract

Genetic counseling may be offered to families with melanoma and to individuals with multiple melanomas to better understand the genetic susceptibility of the disease, the influence of environmental factors, the inheritance of the risk, and behavior that decreases the risk of dying from melanoma, including specific dermatological follow-up such as total body photography and digital dermoscopy. Genetic testing may be offered to those individuals with more than a 10% chance of being a carrier of a mutation. This risk varies according to the incidence of melanoma in the country and sun behavior. In countries with a low-medium incidence of melanoma, genetic testing should be offered to families with two cases of melanoma or an individual with two primary melanomas. In countries with a high incidence, families with three cases of melanoma, with two melanomas and one pancreatic adenocarcinoma, or patients with three primary melanomas, may benefit from genetic testing.

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Figures

Figure 1
Figure 1
Pedigree of a CDKN2A mutation carrier family with 3 melanoma cases
See this image and copyright information in PMC

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