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. 2012 Oct 8;2(5):e001810.
doi: 10.1136/bmjopen-2012-001810. Print 2012.

Mortality in schizophrenia and related psychoses: data from two cohorts, 1875-1924 and 1994-2010

David Healy  1 , Joanna Le Noury, Margaret Harris, Mohammed Butt, Stefanie Linden, Chris Whitaker, Lu Zou, Anthony P Roberts
Affiliations

Mortality in schizophrenia and related psychoses: data from two cohorts, 1875-1924 and 1994-2010

David Healy et al. BMJ Open. .

Abstract

Objective: To investigate death rates in schizophrenia and related psychoses.

Design: Data from two epidemiologically complete cohorts of patients presenting for the first time to mental health services in North Wales for whom there are at least 1, and up to 10-year follow-up data have been used to calculate survival rates and standardised death rates for schizophrenia and related psychoses.

Setting: The North Wales Asylum Denbigh (archived patient case notes) and the North West Wales District General Hospital psychiatric unit.

Population: Cohort 1: The North Wales Asylum Denbigh (archived patient case notes). Of 3168 patients admitted to the North Wales Asylum Denbigh 1875-1924, 1074 had a schizophrenic or related psychosis. Cohort 2: Patients admitted between 1994 and 2010 to the North West Wales District General Hospital psychiatric unit, of whom 355 had first admissions for schizophrenia or related psychoses.

Results: We found a 10-year survival probability of 75% in the historical cohort and a 90% survival probability in the contemporary cohort with a fourfold increase in standardised death rates in schizophrenia and related psychoses in both historical and contemporary periods. Suicide is the commonest cause of death in schizophrenia in the contemporary period (SMR 35), while tuberculosis was the commonest cause historically (SMR 9). In the contemporary data, deaths from cardiovascular causes arise in the elderly and deaths from suicide in the young.

Conclusions: Contemporary death rates in schizophrenia and related psychoses are high but there are particular hazards and windows of risk that enable interventions. The data point to possible interventions in the incident year of treatment that could give patients with schizophrenia a normal life expectancy.

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Figures

Figure 1
Figure 1
(A) Survival probabilities in all psychose in contemporary and historical cohorts. (B) Survival probabilities in schizophrenia (F20, 25 and 061) in contemporary and historical cohorts. (C) Survival probabilities in other psychoses (F22, 23 and 29) in contemporary and historical cohorts.
See this image and copyright information in PMC

References

    1. Mortensen P, Juel N. Mortality and causes of death in first admitted schizophrenic patients. Br J Psychiatry 1993;163:183–9 - PubMed
    1. Harris EC, Barraclough B. Suicide as an outcome for mental disorders: a meta-analysis. Br J Psychiatry 1997;170:205–28 - PubMed
    1. Brown S, Inskip H, Barraclough B. Causes of the excess mortality of schizophrenia. Br J Psychiatry 2000;177:212–17 - PubMed
    1. Joukamaa M, Heliövaara M, Knekt P, et al. Schizophrenia, neuroleptic medication and mortality. Br J Psychiatry 2006;188:122–7 - PubMed
    1. Colton CW, Manderscheid RW. Congruencies in increased mortality rates, years of potential life lost, and causes of death among public mental health clients in eight states. Prev Chronic Dis 2006;3:0180. http://www.cdc.gov/pcd/issues/2006/apr/05_0180.htm - PMC - PubMed

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