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. 2012:2012:317125.
doi: 10.1155/2012/317125. Epub 2012 Sep 25.

Effect of high-dose oral rabeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers

Hyung-Keun Kim  1 , Jin-Soo Kim, Tae-Ho Kim, Chang-Whan Kim, Young-Seok Cho, Sung-Soo Kim, Hiun-Suk Chae, Sok-Won Han, Yong-Wan Park, Hye-Suk Son, Jeong-Yo Min, Guen-Jong Cho, Jung-Sun Bag, Son-Ook Choi
Affiliations

Effect of high-dose oral rabeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers

Hyung-Keun Kim et al. Gastroenterol Res Pract. 2012.

Abstract

Background. The aim of this study was to compare the effect of high-dose oral rabeprazole versus high-dose IV PPI on rebleeding after endoscopic treatment of bleeding peptic ulcers. Methods. This was a two-center, prospective, randomized, controlled trial. Patients with a high-risk bleeding peptic ulcer had endoscopic hemostasis and were randomly assigned to the high-dose oral rabeprazole group (20 mg twice daily for 72 hours) or the high-dose IV omeprazole group (80 mg as a bolus injection followed by continuous infusion at 8 mg/h for 72 hours). Results. The study was stopped because of slow enrollment (total n = 106). The rebleeding rates within 3 days were 3.7% (2 of 54 patients) given oral rabeprazole and 1.9% (1 of 52 patients) given IV omeprazole (P = 1.000). The rebleeding rates after 3 days were 1.9% and 0% (P = 1.000), respectively. The surgical intervention rates were 3.7% and 0% (P = 0.495), and the mortality rates were 1.9% and 0% (P = 1.000), respectively. Conclusions. The effect of high-dose oral rabeprazole did not differ significantly from that of high-dose IV omeprazole on rebleeding, surgical intervention, or mortality after endoscopic treatment of bleeding peptic ulcers, but this requires further evaluation.

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Figures

Figure 1
Figure 1
Flow chart. *For full details of patients who discontinued or dropped out, see Table 4.
See this image and copyright information in PMC

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