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. 2012 Sep;4(9):384-8.
doi: 10.4103/1947-2714.100980.

Aplastic anemia: a common hematological abnormality among peripheral pancytopenia

Haldar Biswajit  1 , Pal Partha Pratim, Sarkar Tarun Kumar, Sharma Shilpi, Goswami Bidyut Krishna, Aikat Aditi
Affiliations

Aplastic anemia: a common hematological abnormality among peripheral pancytopenia

Haldar Biswajit et al. N Am J Med Sci. 2012 Sep.

Abstract

Background: Aplastic anemia is a well-recognized form of marrow failure. The incidence of aplastic anemia is subjected to wide variation. Most cases are acquired and immune-mediated but there are also inherited forms.

Aim: The study was conducted to assess the magnitude of the problem, morphological changes and determinants of aplastic anemia in North Bengal.

Materials and methods: A cross-sectional study had been conducted for a period of one year among 5 to 70 years age group. Initially complete blood count followed by bone marrow examination was done for diagnosis.

Results: Out of 48 cases, 38 (79.17%) had hypocellular diagnosed as aplastic anemia, 5 (10.42%) each had normocellular and hypercellular bone marrow. Histopathology shows that 30 (78.95%) cases had increased iron stores in bone marrow and 8 (21.05%) cases had decreased iron stores. Subjects less than 20 years of age mostly (31.58%) suffered from non-severe disease in contrast to subjects in higher age groups who had severe or very severe disease, though the trend was not significantly different (χ(2) for linear trend 0.171, P > 0.05).

Conclusion: The study shows aplastic anemia is a common hematological abnormality among peripheral pancytopenia in North Bengal region where males were affected more than females.

Keywords: Aplastic anemia; non specific symptoms; north bengal region; peripheral pancytopenia.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Hypocellular marrow with fat space (aspiration 10X, Leishman stain)Microscopically the aspiration material showed a small nodular area (“hot spots”) consisting of all types of marrow cell, which in turn was surrounded by large fatty spaces
See this image and copyright information in PMC

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