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. 1990 Feb;49(2):354-8.
doi: 10.1097/00007890-199002000-00025.

Transplantation in HIV+ patients

A G Tzakis  1 , M H Cooper, J S Dummer, M Ragni, J W Ward, T E Starzl
Affiliations

Transplantation in HIV+ patients

A G Tzakis et al. Transplantation. 1990 Feb.

Abstract

Twenty-five whole-organ recipients treated from 1981 through September 1988 were HIV carriers. Eleven were infected before transplantation, although this was not known until later in 8 recipients. The other 14 were infected perioperatively. Ten of the 25 recipients were infants or children. The organs transplanted were the liver (n = 15), and the heart or kidney (n = 5, each). After a mean follow-up of 2.75 years (range, 0.7-6.6 years), 13 recipients are alive. Survival is 7/15, 2/5, and 4/5 of the liver, heart, and kidney recipients, respectively. The best results were in the pediatric group (70% survival) in which only 1 of 10 patients died of AIDS. In contrast, AIDS caused the death of 5 of 15 adult recipients and was the leading cause of death. Transplantation plus immunosuppression appeared to shorten the AIDS-free time in HIV+ patients as compared to nontransplant hemophiliac and transfusion control groups. Accrual of HIV+ transplant recipients has slowed markedly since the systematic screening of donors, recipients, and blood products was begun in 1985.

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Figures

Figure 1
Figure 1
Kaplan-Meier survival estimates comparing HIV− liver transplant recipients to HIV+ transplant recipients.
Figure 2
Figure 2
Kaplan-Meier survival estimates for HIV+ transplant recipients, Pittsburgh, P A.
Figure 3
Figure 3
Kaplan-Meier estimates for the proportion of HIV+ transplant recipients who remain AIDS free.
Figure 4
Figure 4
Kaplan-Meier estimates for the proportion remaining AIDS free comparing HIV+ transplant recipients to hemophiliacs transfusion recipients.
See this image and copyright information in PMC

References

    1. L'Age-Stehr J, Schwarz A, Offerman G, et al. HTLV-III infection in kidney transplant recipients. Lancet. 1985;2:1361. - PubMed
    1. Prompt CA, Reis MM, Grillo FM, et al. Transmission of AIDS virus at renal transplantation. Lancet. 1985;2:672. - PubMed
    1. Dummer JS, Erb S, Breinig MK, et al. Infection with human immunodeficiency virus in the Pittsburgb transplant population: a study of 583 donors and 1043 recipients 1981–1986. Transplantation. 1989;47:134. - PMC - PubMed
    1. Shaffer D, Pearl RH, Jenkins RL, et al. HTLV-III/LAV infection in kidney and liver transplantation. Transplant Proc. 1987;19:2176. - PubMed
    1. Kerman RH, Flechner SM, Van Buren CT, et al. Investigation of HTLV-3 serology in a renal transplant population. Transplantation. 1987;43:244. - PubMed

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