Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Apr;16(2):247-52.
doi: 10.4103/0972-124X.99270.

The use of a natural osteoconductive porous bone mineral (Bio-Oss™) in infrabony periodontal defects

Shankar T Gokhale  1 , C D Dwarakanath
Affiliations

The use of a natural osteoconductive porous bone mineral (Bio-Oss™) in infrabony periodontal defects

Shankar T Gokhale et al. J Indian Soc Periodontol. 2012 Apr.

Abstract

Aim: The aim of the present study was to evaluate the efficacy of a bovine derived xenograft Bio-Oss™ and to compare with open flap debridement in human infrabony periodontal defects.

Materials and methods: Twelve healthy patients (5 males, 7 females; aged 30-50 years), with no systemic disease with moderate to severe periodontitis were treated. Surgically defects were included only if presence of two or more vertical osseous defects as verified by radiographs with associated probing pocket depth of ≥5.0 mm following non-surgical therapy. Final selection included 24 defects. The defects were randomly assigned treatment with bovine derived xenograft Bio-Oss™ as experimental sites or open flap debridement as control sites. Soft tissue and hard tissue measurements were recorded on the day of surgery and six months post-operatively.

Results: The results showed significant difference statistically between experimental and control sites in all measurements. Soft tissue measurements for the experimental sites included probing pocket depth reduction of 4.33±0.651 mm and attachment gain of 2.92±0.9003 mm, while the control sites showed a probing pocket depth reduction of 2.92±0.669 mm and a attachment gain of 0.583±0.515 mm. Osseous measurements showed bone fill of 1.936±1.046 mm (54.065±12.642%) for experimental sites and 0.02±0.01 mm (0.534±0.384%) for the control sites. Defect resolution was 50.75% for the experimental sites and 5.45% for the control sites.

Conclusion: Bio-Oss™ is a bone graft material of considerable promise. However, further long term clinical studies with histological evaluation are warranted.

Keywords: Alveolar bone loss/surgery; Bio-Oss™; bone substitute; bone transplantation; cattle; periodontitis/surgery.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
(a) Infrabony defect (mesial to lateral incisor) in the experimental group after debridement; (b) Baseline radiograph showing infrabony defect mesial to lateral incisor; (c) Bio-Oss™ packed into the defect; (d) 6-month post-operative radiograph showing bone fill
Figure 2
Figure 2
(a) Baseline radiograph showing infrabony defect mesial to first premolar; (b) 6-month post-operative radiograph showing bone fill
Figure 3
Figure 3
Comparison of variables among study groups before experiment
Figure 4
Figure 4
Comparison of variables among study groups before experiment
Figure 5
Figure 5
Comparison of reduction in plaque and gingival Index at the end of study period
Figure 6
Figure 6
Comparison of mean changes in soft tissue variables between study groups
Figure 7
Figure 7
Comparison of mean changes in hard tissue variables (in millimeters) between study groups
Figure 8
Figure 8
Comparison of mean changes in hard tissue variables (in percentage) between study groups
See this image and copyright information in PMC

References

    1. Schluger S. Osseous resection- A basic principle in periodontal surgery. Oral Surg Oral Med Oral Pathol. 1949;2:316–25. - PubMed
    1. Bowers G, Chadroff B, Carnevale R, Mellonig J, Corio R, Emerson J, et al. Histologic evaluation of new attachment apparatus formation in humans. Part III. J Periodontol. 1989;60:683–93. - PubMed
    1. Caton J, Nyman S, Zander H. Histometric evaluation of periodontal surgery.II.Connective tissue attachment levels after four regenerative procedures. J Clin Periodontol. 1980;7:224–31. - PubMed
    1. Cortellini P, Bowers G. Periodontal regeneration of intrabony defects: An evidence based treatment approach. Int J Periodontol Rest Dent. 1995;15:128–45. - PubMed
    1. Listgarten MA, Rosenberg MM. Histological study of repair following new attachment procedures in human periodontal lesions. J Periodontol. 1979;50:333–44. - PubMed