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. 2012;9(10):e1001324.
doi: 10.1371/journal.pmed.1001324. Epub 2012 Oct 9.

Serious and life-threatening pregnancy-related infections: opportunities to reduce the global burden

Courtney A Gravett  1 , Michael G Gravett, Emily T Martin, Jeffrey D Bernson, Sadaf Khan, David S Boyle, Sophia M R Lannon, Janna Patterson, Craig E Rubens, Matthew S Steele
Affiliations

Serious and life-threatening pregnancy-related infections: opportunities to reduce the global burden

Courtney A Gravett et al. PLoS Med. 2012.

Abstract

Michael Gravett and colleagues review the burden of pregnancy-related infections, especially in low- and middle-income countries, and offer suggestions for a more effective intervention strategy.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Literature review strategy.
Relevant studies from the years 1980 to 2012 were identified by searching PubMed, Medline, Embase, and WHO publications. The search strategy used was “([infectious syndrome]) AND (Africa OR Asia OR India OR Thailand OR Bangladesh)”; the infectious syndromes included in our search were those that cause the most morbidity and mortality: puerperal sepsis (PPE, chorioamnionitis), septic abortion, pyelonephritis or urosepsis, and soft tissue infections (necrotizing fasciitis, group A streptococcal infection, and methicillin-resistant staphylococcal infection). All titles and abstracts were reviewed, and those including etiology, prevalence, or pregnancy were selected for further analysis.
Figure 2
Figure 2. Timing of four clinical syndromes and their pathogens, and potential opportunities for “bundled” diagnostic–therapeutic interventions.
See Table 2 for further details of the interventions.
See this image and copyright information in PMC

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