Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2008 Apr;13(2):88-92.
doi: 10.5863/1551-6776-13.2.88.

Elevated tobramycin concentrations following endotracheal administration in a premature infant

Amanda Howard-Thompson  1 , Michael L Christensen
Affiliations
Case Reports

Elevated tobramycin concentrations following endotracheal administration in a premature infant

Amanda Howard-Thompson et al. J Pediatr Pharmacol Ther. 2008 Apr.

Abstract

The following case report describes a 1-month-old, 34-week-gestation premature neonate who had compromised renal function. The neonate received endotracheally administered tobramycin (300 mg every 12 hours) via a PARI PLUS reusable nebulizer to treat a documented Gram-negative tracheostomy infection. The patient also received systemic tobramycin (2.5 mg/kg intravenously every 18 hours). The tobramycin serum concentration obtained 45 hours after the last intravenous dose and 11.5 hours after the second nebulized dose was 17.6 mg/L. The tobramycin nebulizations were stopped.

Keywords: endotracheal; neonate; tobramycin.

PubMed Disclaimer

Figures

Figure.
Figure.
Tobramycin serum concentrations. Time zero is when the last dose of IV tobramycin was given. The first concentration (4.9 mg/L) was obtained on NICU Day 16, 18 hours after the last IV dose of tobramycin. The arrows are the times of ET tobramycin administration. The line at 2 mg/L represents the usual maximum nadir tobramycin serum concentration.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Klastersky J, Geuning C, Mouawad E, Daneau D. Endotracheal gentamicin in bronchial infections in patients with tracheostomy. Chest. 1972;61:117–120. - PubMed
    1. Klastersky J, Huysmans E, Weerts D. Endotracheally administered gentamicin for the prevention of infections of the respiratory tract in patients with tracheostomy: A double-blind study. Chest. 1974;65:650–654. et al. - PubMed
    1. Odio W, VanLaer E, Klastersky J. Concentrations of gentamicin in bronchial secretions after intramuscular and endotracheal administration. J Clin Pharmacol. 1975;15:518–524. - PubMed
    1. Park DR. The microbiology of ventilator-associated pneumonia. Respir Care. 2005;50:742–763. - PubMed
    1. Gough PA, Jordan NS. A review of the therapeutic efficacy of aerosolized and endotracheally instilled antibiotics. Pharmacotherapy. 1982;2:367–377. - PubMed

Publication types

LinkOut - more resources