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Case Reports
. 2008 Apr;13(2):88-92.
doi: 10.5863/1551-6776-13.2.88.

Elevated tobramycin concentrations following endotracheal administration in a premature infant

Amanda Howard-Thompson  1 , Michael L Christensen
Affiliations
Case Reports

Elevated tobramycin concentrations following endotracheal administration in a premature infant

Amanda Howard-Thompson et al. J Pediatr Pharmacol Ther. 2008 Apr.

Abstract

The following case report describes a 1-month-old, 34-week-gestation premature neonate who had compromised renal function. The neonate received endotracheally administered tobramycin (300 mg every 12 hours) via a PARI PLUS reusable nebulizer to treat a documented Gram-negative tracheostomy infection. The patient also received systemic tobramycin (2.5 mg/kg intravenously every 18 hours). The tobramycin serum concentration obtained 45 hours after the last intravenous dose and 11.5 hours after the second nebulized dose was 17.6 mg/L. The tobramycin nebulizations were stopped.

Keywords: endotracheal; neonate; tobramycin.

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Figures

Figure.
Figure.
Tobramycin serum concentrations. Time zero is when the last dose of IV tobramycin was given. The first concentration (4.9 mg/L) was obtained on NICU Day 16, 18 hours after the last IV dose of tobramycin. The arrows are the times of ET tobramycin administration. The line at 2 mg/L represents the usual maximum nadir tobramycin serum concentration.
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