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. 2012;7(10):e46370.
doi: 10.1371/journal.pone.0046370. Epub 2012 Oct 3.

Association study of gene LPP in women with polycystic ovary syndrome

Bo Zhang  1 , Han Zhao, Tao Li, Xuan Gao, Qin Gao, Rong Tang, Jiangtao Zhang, Zi-Jiang Chen
Affiliations

Association study of gene LPP in women with polycystic ovary syndrome

Bo Zhang et al. PLoS One. 2012.

Abstract

Background: Previous genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in Han Chinese population has found that SNPs in LPP gene were nominally significant in PCOS patients (P around 10E-05). Replication of the GWAS was applied to further confirm the relationship between LPP gene and PCOS.

Methods: Three polymorphisms of LPP gene (rs715790, rs4449306, rs6782041) were selected and replicated in additional 1132 PCOS cases and 1142 controls. Genotyping of LPP gene was carried out by Taqman-MGB method.

Results: In rs715790, the allele frequency is significantly different between the PCOS group and the control group. Meta-analysis showed that the allele frequencies of the three SNPs rs715790 (P(meta) =1.89E-05, OR=1.23), rs4449306 (P(meta) =3.0E-04, OR=1.10), rs6782041 (P(meta) = 2.0E-04, OR=1.09), were significantly different between PCOS cases and controls.

Conclusions: Our results suggest that LPP gene might be a novel candidate for PCOS.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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