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Randomized Controlled Trial
. 2013 Mar;56(3):316-9.
doi: 10.1097/MPG.0b013e3182758c4a.

Blood lead concentration is not altered by high-dose vitamin D supplementation in children and young adults with HIV

Veronique Groleau  1 , Rachel A Herold, Joan I Schall, Julia L Wagner, Kelly A Dougherty, Babette S Zemel, Richard M Rutstein, Virginia A Stallings
Affiliations
Randomized Controlled Trial

Blood lead concentration is not altered by high-dose vitamin D supplementation in children and young adults with HIV

Veronique Groleau et al. J Pediatr Gastroenterol Nutr. 2013 Mar.

Abstract

Objectives: Optimal vitamin D status is known to have beneficial health effects and vitamin D supplements are commonly used. It has been suggested that vitamin D supplementation may increase blood lead in children and adults with previous lead exposure. The objective was to determine the safety regarding lead toxicity during 12 weeks of high-dose vitamin D3 supplementation in children and young adults with human immunodeficiency virus (HIV).

Methods: Subjects with HIV (8-24 years) were randomized to vitamin D3 supplementation of 4000 or 7000 IU/day and followed at 6 and 12 weeks for changes in serum 25-hydroxy vitamin D (25D) and whole-blood lead concentration. This was a secondary analysis of a larger study of vitamin D3 supplementation in children and adolescents with HIV.

Results: In 44 subjects (75% African American), the baseline mean ± standard deviation serum 25D was 48.3±18.6 nmol/L. Fifty percent of subjects had baseline serum 25D <50.0 nmol/L. Serum 25D increased significantly with D3 supplementation during the 12 weeks. No subject had a whole-blood lead >5.0 μg/dL at baseline or during subsequent visits. Whole-blood lead and 25D were not correlated at baseline, and were negatively correlated after 12 weeks of supplementation (P=0.014). Whole-blood lead did not differ between those receiving 4000 and 7000 IU of vitamin D3.

Conclusions: High-dose vitamin D3 supplementation and the concomitant increased serum 25D did not result in increased whole-blood lead concentration in this sample of children and young adults living in a northeastern urban city.

Trial registration: ClinicalTrials.gov NCT01092338.

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Conflict of interest statement

The authors declare they have no or potential competing financial interest.

Figures

Figure 1
Figure 1
Whole blood lead level is presented over time (0 = baseline, 6 = 6 weeks, 12 = 12 weeks) separately by age group: age 8 to 12.9, age 13 to 18.9 and age 19 to 24.9. The horizontal lines represent the median values in blood lead level. The Figure shows a higher whole blood lead throughout the study in the youngest age group compared to both older age groups (p ≤ 0.02).
See this image and copyright information in PMC

References

    1. Herr C, Greulich T, Koczulla RA, et al. The role of vitamin D in pulmonary disease: COPD, asthma, infection and cancer. Respir Res. 2011;12:31. - PMC - PubMed
    1. Bischoff-Ferrari HA, Dawson-Hughs B, Stocklin E, et al. Oral supplementation with 25(OH)D(3) versus vitamin D(3): effects on 25(OH)D levels, lower extremity function, blood pressure and markers of innate immunity. J Bone Miner Res. 2011 doi: 10.1002/jbmr.551. Online 25 October 2011. - DOI - PubMed
    1. Jackson RD, LaCroix AZ, Gass M, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006;354(7):669–83. - PubMed
    1. Spector SA. Vitamin D and HIV: letting the sun shine in. Top Antivir Med. 2011;19(1):6–10. - PMC - PubMed
    1. Wintergerst ES, Maggini S, Hornig DH. Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab. 2007;51(4):301–23. - PubMed

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