Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Oct 11;490(7419):187-91.
doi: 10.1038/nature11556.

A call for transparent reporting to optimize the predictive value of preclinical research

Story C Landis  1 , Susan G Amara, Khusru Asadullah, Chris P Austin, Robi Blumenstein, Eileen W Bradley, Ronald G Crystal, Robert B Darnell, Robert J Ferrante, Howard Fillit, Robert Finkelstein, Marc Fisher, Howard E Gendelman, Robert M Golub, John L Goudreau, Robert A Gross, Amelie K Gubitz, Sharon E Hesterlee, David W Howells, John Huguenard, Katrina Kelner, Walter Koroshetz, Dimitri Krainc, Stanley E Lazic, Michael S Levine, Malcolm R Macleod, John M McCall, Richard T Moxley 3rd, Kalyani Narasimhan, Linda J Noble, Steve Perrin, John D Porter, Oswald Steward, Ellis Unger, Ursula Utz, Shai D Silberberg
Affiliations

A call for transparent reporting to optimize the predictive value of preclinical research

Story C Landis et al. Nature. .

Abstract

The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.

PubMed Disclaimer

Comment in

References

    1. Begley CG, Ellis LM. Raise standards for preclinical cancer research. Nature. 2012;483:531–533. - PubMed
    1. Hess KR. Statistical design considerations in animal studies published recently in Cancer Research. Cancer Res. 2011;71:625. - PubMed
    1. Kilkenny C, et al. Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS ONE. 2009;4:e7824. - PMC - PubMed
    1. Moher D, Simera I, Schulz KF, Hoey J, Altman DG. Helping editors, peer reviewers and authors improve the clarity, completeness and transparency of reporting health research. BMC Med. 2008;6:13. - PMC - PubMed
    1. Prinz F, Schlange T, Asadullah K. Believe it or not: how much can we rely on published data on potential drug targets? Nature Rev Drug Discov. 2011;10:712. The first report that many published studies cannot be reproduced by the pharmaceutical industry. - PubMed

Publication types