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Case Reports
. 2012 Oct;26(5):388-90.
doi: 10.3341/kjo.2012.26.5.388. Epub 2012 Sep 12.

A case of cystoid macular edema associated with Paclitaxel chemotherapy

Dong Sik Ham  1 , Joo Eun Lee, Hyun Woong Kim, Il Han Yun
Affiliations
Case Reports

A case of cystoid macular edema associated with Paclitaxel chemotherapy

Dong Sik Ham et al. Korean J Ophthalmol. 2012 Oct.

Abstract

We encountered a patient with cystoid macular edema (CME) secondary to paclitaxel use. A 57-year-old man presented with gradual decreased bilateral vision. His chemotherapeutic regimen consisted of bevacizumab, paclitaxel (175 mg/m(2) for 5 months), and carboplatin. Optical coherence tomography imaging revealed bilateral CME greater than 500 µm. However, one year later, visual acuity was improved, best-corrected Snellen visual acuity was 40 / 80 in each eye, and CME was spontaneously improved. Our study confirmed that macular edema associated with paclitaxel use shows spontaneous resolution and improvement of visual acuity after a change of chemotherapeutic regimen.

Keywords: Macular edema; Paclitaxel.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
(A-D) The right eye of the patient. (A) Before intravitreal bevacizumab plus triamcinolone injection, fundus showed cystic change of the macula. (B) Fluorescein angiograms (FA) showed hyperfluorescence in the macula in the late frame. (C) Optical coherence tomography (OCT) showed cystoid macular edema (CME). (D) Six weeks after the injection, CME was unchanged in OCT. (E-H) The left eye of the patient. (E) Before intravitreal bevacizumab plus triamcinolone injection, fundus showed cystic change of the macula. (F) FA showed hyperfluorescence in the macula in the late frame. (G) OCT showed CME. (H) Six weeks after the injection, CME was unchanged in OCT.
Fig. 2
Fig. 2
The right (A) and left (B) eyes of the patient. One year later, optical coherence tomography showed cystoid macular edema improved. The central retinal thickness was decreased from 502 µm to 246 µm in the right eye and from 513 µm to 228 µm in the left eye.
See this image and copyright information in PMC

References

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