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. 2012 Nov;26(6):515-24.
doi: 10.1111/ppe.12006. Epub 2012 Sep 24.

Descriptive epidemiology of non-syndromic complete atrioventricular canal defects

A J Agopian  1 , Mousumi Moulik, Monesha Gupta-Malhotra, Lisa K Marengo, Laura E Mitchell
Affiliations

Descriptive epidemiology of non-syndromic complete atrioventricular canal defects

A J Agopian et al. Paediatr Perinat Epidemiol. 2012 Nov.

Abstract

Background: Complete atrioventricular canal defects (CAVC) are a common heart defect, but few epidemiologic studies have evaluated non-syndromic CAVC. Risk factors for non-syndromic CAVC have not been well established.

Methods: To assess the relationship between risk for non-syndromic CAVC in offspring and several sociodemographic and reproductive parental factors, including maternal diabetes and obesity, we conducted Poisson regression analyses, using data ascertained through the Texas Birth Defects Registry, a large, population-based birth defects registry. Data were evaluated for 563 non-syndromic cases with CAVC.

Results: Significant associations were observed between non-syndromic CAVC in offspring and maternal pregestational diabetes (adjusted prevalence ratio (aPR) 6.74; 95% confidence interval (CI) 3.67, 12.37), gestational diabetes (aPR 1.69; 95% CI 1.03, 2.79) and obesity (aPR 1.69; 95% CI 1.24, 2.30).

Conclusions: Our findings add non-syndromic CAVC to the growing list of birth defects that appear to be associated with maternal diabetes and obesity.

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Supplementary concepts