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Comment
. 2012 Oct 10;20(10):1617-9.
doi: 10.1016/j.str.2012.09.008.

Fragment and conquer: from structure to complexes to function

Jean-François Guichou  1 , Gilles Labesse
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Fragment and conquer: from structure to complexes to function

Jean-François Guichou et al. Structure. .
Free article

Abstract

In this issue of Structure, Shumilin and colleagues show the power of metabolite screening by means of X-ray crystallography to link an orphan protein domain with an orphan biochemical function. This result paves the way for large-scale functional annotation and sets new objectives for structural genomics.

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