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Comment
. 2012 Oct 10;20(10):1619-20.
doi: 10.1016/j.str.2012.09.007.

WW domains in the heart of Smad regulation

Marius Sudol  1
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WW domains in the heart of Smad regulation

Marius Sudol. Structure. .
Free article

Abstract

WW domains are small modules that mediate protein/protein interactions. In this issue of Structure, Aragón and colleagues show that a WW domain of YAP can mediate complexes with either the canonical PY motif in an inhibitory Smad or engage in phosphorylation-dependent complexes with one of the activated Smads. The propensity of YAP WW to recognize a pSP motif is a surprising find with a number of far-reaching ramifications.

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