Comment
doi: 10.1016/j.cell.2012.09.028.
The problem with mixing mitochondria
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- PMID: 23063117
- DOI: 10.1016/j.cell.2012.09.028
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Comment
The problem with mixing mitochondria
Cell.
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Free article
Erratum in
- Cell. 2013 Jan 17;152(1-2):365
Abstract
Mixing of mitochondrial DNAs (heteroplasmy) is unfavorable for reasons unknown. Sharpley et al. show that heteroplasmy has surprising genetic and behavioral effects in mice, even when each haplotype alone produces a normal phenotype. This interference is bioenergetic and may have contributed to the evolution of sexes.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition.Cell. 2012 Oct 12;151(2):333-343. doi: 10.1016/j.cell.2012.09.004. Cell. 2012. PMID: 23063123 Free PMC article.
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