Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Dec;181(6):1900-2.
doi: 10.1016/j.ajpath.2012.09.020. Epub 2012 Oct 11.

Regulatory T cells in preeclampsia: some answers, more questions?

Affiliations
Comment

Regulatory T cells in preeclampsia: some answers, more questions?

Ana S Cerdeira et al. Am J Pathol. 2012 Dec.

Abstract

This Commentary highlights the article by Hsu et al (in this issue) reporting an enrichment in induced regulatory T cells (iTregs) in normal pregnancy but not in preeclampsia, implicating iTreg defect as central to the pathogenesis of preeclampsia.

PubMed Disclaimer

Comment on

References

    1. Aluvihare V.R., Kallikourdis M., Betz A.G. Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol. 2004;5:266–271. - PubMed
    1. Littman D.R., Rudensky A.Y. Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 2010;140:845–858. - PubMed
    1. Lee H.M., Bautista J.L., Hsieh C.S. Thymic and peripheral differentiation of regulatory T cells. Adv Immunol. 2011;112:25–71. - PubMed
    1. Hsu P., Nanan B.S., Dahlstrom J.E., Fadia M., Arin C., Peek M., Nanan R. Altered decidual DC-SIGN antigen presenting cells and impaired regulatory T cell induction in preeclampsia. Am J Pathol. 2012;181:2149–2160. - PubMed
    1. Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009;33:130–137. - PubMed

MeSH terms

Substances