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. 2012 Mar;4(Suppl 1):S112-3.
doi: 10.4103/0975-7406.94161.

Effect of different lipids and surfactants on formulation of solid lipid nanoparticles incorporating tamoxifen citrate

S U Upadhyay  1 , J K Patel, V A Patel, A K Saluja
Affiliations

Effect of different lipids and surfactants on formulation of solid lipid nanoparticles incorporating tamoxifen citrate

S U Upadhyay et al. J Pharm Bioallied Sci. 2012 Mar.

Abstract

Tamoxifen Citrate (TC) is an estrogen receptor antagonist and drug of choice for hormone sensitive breast cancer. Solid Lipid Nanoparticles loaded with TC were prepared by High Shear Homogenization followed by Ultrasonication. The aim of the present work is to study the effect of four different Solid Lipids and three Surfactants on Formulation and Stability of SLN. They were characterized for Particle size, Polydispersity Index and Zeta Potential by Zetasizer Nano. SLN prepared by Solid Lipid Compritol 888 (Glyceryldibehenate) and Tween 80 (1%) showed desired Particle Size of 206.9 nm, PDI of 0.046 and Zeta Potential of 9.32 mV.

Keywords: Nanoparticles; Tween 80; surfactants.

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Conflict of interest statement

Conflict of Interest: None declared.

References

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