Applications of immunohistochemistry
- PMID: 23066277
- PMCID: PMC3467869
- DOI: 10.4103/0975-7406.100281
Applications of immunohistochemistry
Abstract
Immunohistochemistry (IHC) is an important application of monoclonal as well as polyclonal antibodies to determine the tissue distribution of an antigen of interest in health and disease. IHC is widely used for diagnosis of cancers; specific tumor antigens are expressed de novo or up-regulated in certain cancers. This article deals with the various applications of IHC in diagnosis of diseases, with IHC playing an important role in diagnostic and research laboratories.
Keywords: Antibody; antigen; disease; immunohistochemistry.
Conflict of interest statement
References
-
- Ajura AJ, Sumairi I, Lau SH. The use of immunohistochemistry in an oralpathology laboratory, Malays. J Pathol. 2007;29:101–5. - PubMed
-
- Edgar MA, Rosenblum MK. The differential diagnosis of central nervous system tumors: A critical examination of some recent immunohistochemical applications. Arch Pathol Lab Med. 2008;132:500–9. - PubMed
-
- Garcia CF, Swerdlow SH. Best practices in contemporary diagnostic immunohistochemistry: Panel approach to hematolymphoid proliferations. Arch Pathol Lab Med. 2009;133:756–65. - PubMed
-
- Leong AS, Wright J. The contribution of immunohistochemical staining in tumor diagnosis. Histopathology. 1987;11:1295–305. - PubMed
LinkOut - more resources
Full Text Sources
Other Literature Sources
