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. 2012 Aug;4(Suppl 2):S410-3.
doi: 10.4103/0975-7406.100309.

Bisphosphonates: An update

Nalliappan Ganapathy  1 , Subramanium Gokulnathan, Nataraj Balan, Thangadurai Maheswaran, Venkatesan
Affiliations

Bisphosphonates: An update

Nalliappan Ganapathy et al. J Pharm Bioallied Sci. 2012 Aug.

Abstract

Bisphosphonates are used widely for variety of bone condition, most notably IV bisphosphonates in the treatment of metastic bone lesion and oral bisphosphonates for osteoporosis. They constitute a group of drugs capable of modulating bone turnover and reducing its remodeling when an excessive resorption occurs. In the last few years, due to their extensive use, many cases of complications associated with their use have been published. This paper provides recent knowledge on general characteristics of these drugs and their mechanism of action, pathogenesis, as well as their relevance to dentist.

Keywords: Bisphosphonate-associated osteonecrosis; osteonecrosis; osteoporosis.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Basic structure of bisphosphonates Simple bisphosphonates Nitrogen-containing bisphosphonates
Figure 2
Figure 2
Chemical structure
Figure 3
Figure 3
Prenylation process
Figure 4
Figure 4
Action of bisphosphonate[5]
Figure 5
Figure 5
Action of nitrogen containing bisphosphonates on osteoclasts
See this image and copyright information in PMC

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