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. 1979 Dec;48(3):215-7.
doi: 10.1007/BF00690522.

Myelin lesions in the rabbit eye model as a bystander effect of herpes simplex and visna virus sensitization

K Kristensson, H Thormar, H M Wisniewski

Myelin lesions in the rabbit eye model as a bystander effect of herpes simplex and visna virus sensitization

K Kristensson et al. Acta Neuropathol. 1979 Dec.

Abstract

Rabbits were immunized with herpes simplex and visna virus in complete Freund's adjuvant. Uv-inactivated herpes virus and the purified visna virus protein p25 injected intraocularly into these rabbits elicited a moderate inflammatory cell infiltration in the epiretinal myelinated nerve fiber bundles accompanied by signs of demyelination. It is therefore apparent that also viral antigen can induce myelin lesions as a so-called "bystander effect" of a cell-mediated immune response (bystander demyelination).

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References

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