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. 2013 Mar;36(3):737-9.
doi: 10.2337/dc12-0852. Epub 2012 Oct 15.

Diabetes genetic predisposition score and cardiovascular complications among patients with type 2 diabetes

Qibin Qi  1 , James B Meigs, Kathryn M Rexrode, Frank B Hu, Lu Qi
Affiliations

Diabetes genetic predisposition score and cardiovascular complications among patients with type 2 diabetes

Qibin Qi et al. Diabetes Care. 2013 Mar.

Abstract

Objective: To examine the association between genetic predisposition to type 2 diabetes (T2D) and risk of cardiovascular disease (CVD) among patients with T2D.

Research design and methods: The current study included 1,012 men and 1,310 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, including 677 patients with CVD and 1,645 non-CVD control subjects. A genetic predisposition score (GPS) was calculated on the basis of 36 established independent diabetes-predisposing variants.

Results: Each additional diabetes-risk allele in the GPS was associated with a 3% increased risk of CVD (odds ratio [OR] 1.03 [95% CI 1.00-1.06]). The OR was 1.47 (1.11-1.95) for CVD risk by comparing extreme quartiles of the GPS (P for trend = 0.01). We also found that the GPS was positively associated with hemoglobin A(1c) levels (P = 0.009).

Conclusions: Genetic predisposition to T2D is associated with an increased risk of cardiovascular complications in patients with T2D.

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