Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Mar;36(3):737-9.
doi: 10.2337/dc12-0852. Epub 2012 Oct 15.

Diabetes genetic predisposition score and cardiovascular complications among patients with type 2 diabetes

Qibin Qi  1 , James B Meigs, Kathryn M Rexrode, Frank B Hu, Lu Qi
Affiliations

Diabetes genetic predisposition score and cardiovascular complications among patients with type 2 diabetes

Qibin Qi et al. Diabetes Care. 2013 Mar.

Abstract

Objective: To examine the association between genetic predisposition to type 2 diabetes (T2D) and risk of cardiovascular disease (CVD) among patients with T2D.

Research design and methods: The current study included 1,012 men and 1,310 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, including 677 patients with CVD and 1,645 non-CVD control subjects. A genetic predisposition score (GPS) was calculated on the basis of 36 established independent diabetes-predisposing variants.

Results: Each additional diabetes-risk allele in the GPS was associated with a 3% increased risk of CVD (odds ratio [OR] 1.03 [95% CI 1.00-1.06]). The OR was 1.47 (1.11-1.95) for CVD risk by comparing extreme quartiles of the GPS (P for trend = 0.01). We also found that the GPS was positively associated with hemoglobin A(1c) levels (P = 0.009).

Conclusions: Genetic predisposition to T2D is associated with an increased risk of cardiovascular complications in patients with T2D.

PubMed Disclaimer

References

    1. Stern MP. Diabetes and cardiovascular disease. The “common soil” hypothesis. Diabetes 1995;44:369–374 - PubMed
    1. Pfister R, Barnes D, Luben RN, Khaw KT, Wareham NJ, Langenberg C. Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease. Diabetologia 2011;54:2283–2287 - PubMed
    1. Colditz GA, Manson JE, Hankinson SE. The Nurses’ Health Study: 20-year contribution to the understanding of health among women. J Womens Health 1997;6:49–62 - PubMed
    1. Rimm EB, Giovannucci EL, Willett WC, et al. Prospective study of alcohol consumption and risk of coronary disease in men. Lancet 1991;338:464–468 - PubMed
    1. Qi L, Cornelis MC, Kraft P, et al. Meta-Analysis of Glucose and Insulin-related traits Consortium (MAGIC) Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet 2010;19:2706–2715 - PMC - PubMed

Publication types