Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jan;2(1):12-7.
doi: 10.4103/2230-973X.96921.

Improvement in solubility of poor water-soluble drugs by solid dispersion

Swati Sareen  1 , George Mathew, Lincy Joseph
Affiliations

Improvement in solubility of poor water-soluble drugs by solid dispersion

Swati Sareen et al. Int J Pharm Investig. 2012 Jan.

Abstract

This article is intended to combine recent literature on solid dispersion technology for solubility enhancement with special emphasis on mechanism responsible for the same by solid dispersion, various preparation methods, and evaluation parameters. Solubility behavior is the most challenging aspect for various new chemical entities as 60% of the new potential products possess solubility problems. This is the biggest reason for new drug molecules not reaching to the market or not reaches to full potential. There are various techniques to enhance the drug solubility such as particle size reduction, nanosuspension, use of surfactants, salt formation, solid dispersion, etc. From this article it may be concluded that solid dispersion is an important approach for improvement of bioavailability of poor water-soluble drugs.

Keywords: Dissolution; electrospinning; eutectic mixture; hydrophobic drugs; lyophilization.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Poutan CW. Formulation of poorly water soluble drugs for oral administration: Physicochemical issue and lipid formulation classification system. Eur J Pharm Sci. 2006;29:278–87. - PubMed
    1. Lipinski CA. Avoiding investment in doomed drugs, is poor solubility an industry wide problem? Curr Drugs Dis. 2001;4:17–9.
    1. Takano N, Kawashima H, Shinoda Y, Inagi T. Solid dispersion composition. United State Patent No.6753330. 2004
    1. Yium C, Tongwen X, Rongquang F. Polyamidoaminedendrimes used as solubility enhancer of ketopfofen. Eur J Med Chem. 2005;40:1390–3. - PubMed
    1. Muller RH, Jacobs C, Kayer O. Nanosuspension for formulation of poorly soluble drugs. In: Nielloud F, Marti-Mesters G, editors. Pharmaceutical emulsion and suspension. New York: Marcel Dekker; 2000. pp. 383–407.