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. 1990 Feb 12;261(1):85-8.
doi: 10.1016/0014-5793(90)80642-v.

Members of the alpha-amylase inhibitors family from wheat endosperm are major allergens associated with baker's asthma

L Gómez  1 , E Martín, D Hernández, R Sánchez-Monge, D Barber, V del Pozo, B de Andrés, A Armentia, C Lahoz, G Salcedo, et al.
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Free article

Members of the alpha-amylase inhibitors family from wheat endosperm are major allergens associated with baker's asthma

L Gómez et al. FEBS Lett. .
Free article

Abstract

We have identified the major antigens or IgE binding components from wheat flour. Thirty-five sera from patients with baker's asthma were used to analyze the reaction with wheat salt-soluble proteins. We found a 15 kDa SDS-PAGE band which reacted with all sera tested. Purified members of the alpha-amylase inhibitor family, which are the main components of the 15 kDa band, were recognized by specific IgE when tested with a pool of reactive sera. Immunodetection after two-dimensional electrophoretic fractionation of crude inhibitor preparations from wheat endosperms also detected several inhibitor subunits as major low-molecular-weight allergens.

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