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. 2012 Nov 2;14(21):5428-31.
doi: 10.1021/ol302496q. Epub 2012 Oct 16.

Halogenation of primary alcohols using a tetraethylammonium halide/[Et2NSF2]BF4 combination

Marie-France Pouliot  1 , Olivier Mahé, Jean-Denys Hamel, Justine Desroches, Jean-François Paquin
Affiliations

Halogenation of primary alcohols using a tetraethylammonium halide/[Et2NSF2]BF4 combination

Marie-France Pouliot et al. Org Lett. .

Abstract

The halogenation of primary alcohols is presented. The use of a combination of tetraethylammonium halide and [Et(2)NSF(2)]BF(4) (XtalFluor-E) allows for chlorination and bromination reactions to proceed efficiently (up to 92% yield) with a wide range of alcohols. Iodination reactions are also possible albeit in lower yields.

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