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Review
. 2013 Feb;175(1-2):129-34.
doi: 10.1007/s11046-012-9591-2. Epub 2012 Oct 17.

Micafungin for Candida albicans pacemaker-associated endocarditis: a case report and review of the literature

Carlo Tascini  1 , Maria Grazia Bongiorni, Enrico Tagliaferri, Antonello Di Paolo, Sarah Flammini, Ezio Soldati, Alessandro Leonildi, Andrea Di Cori, Francesco Menichetti
Affiliations
Review

Micafungin for Candida albicans pacemaker-associated endocarditis: a case report and review of the literature

Carlo Tascini et al. Mycopathologia. 2013 Feb.

Abstract

We report on the treatment with micafungin of a pacemaker-associated endocarditis due to Candida albicans. Antifungal therapy was able to reduce vegetation size from 5 to 1 cm making possible the transvenous removal of the device without a high risk of pulmonary embolism. Noteworthy, a high micafungin concentration was documented into the lead vegetation (10 μg/g of vegetation tissue) and this may have contributed to the striking size reduction of vegetation.

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