New components of the necroptotic pathway

doi:10.1007/s13238-012-2083-9

Review

. 2012 Nov;3(11):811-7.

doi: 10.1007/s13238-012-2083-9. Epub 2012 Oct 17.

New components of the necroptotic pathway

Zhenru Zhou¹, Victor Han, Jiahuai Han

Affiliations

PMID: 23073834
PMCID: PMC4875459
DOI: 10.1007/s13238-012-2083-9

Review

New components of the necroptotic pathway

Zhenru Zhou et al. Protein Cell. 2012 Nov.

. 2012 Nov;3(11):811-7.

doi: 10.1007/s13238-012-2083-9. Epub 2012 Oct 17.

Authors

Zhenru Zhou¹, Victor Han, Jiahuai Han

Affiliation

¹ State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, China.

PMID: 23073834
PMCID: PMC4875459
DOI: 10.1007/s13238-012-2083-9

Abstract

Programmed necrosis, also known as necroptosis, has recently drawn great attention. As an important cellular regulation mechanism, knowledge of its signaling components is expanding. Necroptosisis demonstrated to be regulated by the RIP1 and RIP3 kinases, and its pathophysiological importance has been confirmed in a number of disease models. Here we review the new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI, and discuss some of their possible applications according to recent findings.

PubMed Disclaimer

Cited by

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death.
Chen X, Li W, Ren J, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J. Chen X, et al. Cell Res. 2014 Jan;24(1):105-21. doi: 10.1038/cr.2013.171. Epub 2013 Dec 24. Cell Res. 2014. PMID: 24366341 Free PMC article.
Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution.
Xu W, Jing L, Wang Q, Lin CC, Chen X, Diao J, Liu Y, Sun X. Xu W, et al. Oncotarget. 2015 Oct 6;6(30):30017-34. doi: 10.18632/oncotarget.5013. Oncotarget. 2015. PMID: 26356820 Free PMC article.
Necroptosis in stressed ovary.
Chaudhary GR, Yadav PK, Yadav AK, Tiwari M, Gupta A, Sharma A, Pandey AN, Pandey AK, Chaube SK. Chaudhary GR, et al. J Biomed Sci. 2019 Jan 21;26(1):11. doi: 10.1186/s12929-019-0504-2. J Biomed Sci. 2019. PMID: 30665407 Free PMC article. Review.
Targeting cell death signaling in colorectal cancer: current strategies and future perspectives.
Koehler BC, Jäger D, Schulze-Bergkamen H. Koehler BC, et al. World J Gastroenterol. 2014 Feb 28;20(8):1923-34. doi: 10.3748/wjg.v20.i8.1923. World J Gastroenterol. 2014. PMID: 24587670 Free PMC article. Review.
Key roles of necroptotic factors in promoting tumor growth.
Liu X, Zhou M, Mei L, Ruan J, Hu Q, Peng J, Su H, Liao H, Liu S, Liu W, Wang H, Huang Q, Li F, Li CY. Liu X, et al. Oncotarget. 2016 Apr 19;7(16):22219-33. doi: 10.18632/oncotarget.7924. Oncotarget. 2016. PMID: 26959742 Free PMC article.

See all "Cited by" articles

References

1. Benedict C.A., Norris P.S., Ware C.F. To kill or be killed: viral evasion of apoptosis. Nat Immunol. 2002;3:1013–1018. doi: 10.1038/ni1102-1013. - DOI - PubMed
1. Bertrand M.J., Milutinovic S., Dickson K.M., Ho W.C., Boudreault A., Durkin J., Gillard J.W., Jaquith J.B., Morris S.J., Barker P.A. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell. 2008;30:689–700. doi: 10.1016/j.molcel.2008.05.014. - DOI - PubMed
1. Bonnet M.C., Preukschat D., Welz P.S., van Loo G., Ermolaeva M.A., Bloch W., Haase I., Pasparakis M. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity. 2011;35:572–582. doi: 10.1016/j.immuni.2011.08.014. - DOI - PubMed
1. Brooks C., Wei Q., Feng L., Dong G., Tao Y., Mei L., Xie Z.J., Dong Z. Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc Natl Acad Sci U S A. 2007;104:11649–11654. doi: 10.1073/pnas.0703976104. - DOI - PMC - PubMed
1. Ch’en I.L., Tsau J.S., Molkentin J.D., Komatsu M., Hedrick S.M. Mechanisms of necroptosis in T cells. J Exp Med. 2011;208:633–641. doi: 10.1084/jem.20110251. - DOI - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Research Materials
- NCI CPTC Antibody Characterization Program
Miscellaneous
- NCI CPTAC Assay Portal

[1] Benedict C.A., Norris P.S., Ware C.F. To kill or be killed: viral evasion of apoptosis. Nat Immunol. 2002;3:1013–1018. doi: 10.1038/ni1102-1013. - DOI - PubMed

[2] Benedict C.A., Norris P.S., Ware C.F. To kill or be killed: viral evasion of apoptosis. Nat Immunol. 2002;3:1013–1018. doi: 10.1038/ni1102-1013. - DOI - PubMed

[3] Bertrand M.J., Milutinovic S., Dickson K.M., Ho W.C., Boudreault A., Durkin J., Gillard J.W., Jaquith J.B., Morris S.J., Barker P.A. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell. 2008;30:689–700. doi: 10.1016/j.molcel.2008.05.014. - DOI - PubMed

[4] Bertrand M.J., Milutinovic S., Dickson K.M., Ho W.C., Boudreault A., Durkin J., Gillard J.W., Jaquith J.B., Morris S.J., Barker P.A. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell. 2008;30:689–700. doi: 10.1016/j.molcel.2008.05.014. - DOI - PubMed

[5] Bonnet M.C., Preukschat D., Welz P.S., van Loo G., Ermolaeva M.A., Bloch W., Haase I., Pasparakis M. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity. 2011;35:572–582. doi: 10.1016/j.immuni.2011.08.014. - DOI - PubMed

[6] Bonnet M.C., Preukschat D., Welz P.S., van Loo G., Ermolaeva M.A., Bloch W., Haase I., Pasparakis M. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity. 2011;35:572–582. doi: 10.1016/j.immuni.2011.08.014. - DOI - PubMed

[7] Brooks C., Wei Q., Feng L., Dong G., Tao Y., Mei L., Xie Z.J., Dong Z. Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc Natl Acad Sci U S A. 2007;104:11649–11654. doi: 10.1073/pnas.0703976104. - DOI - PMC - PubMed

[8] Brooks C., Wei Q., Feng L., Dong G., Tao Y., Mei L., Xie Z.J., Dong Z. Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc Natl Acad Sci U S A. 2007;104:11649–11654. doi: 10.1073/pnas.0703976104. - DOI - PMC - PubMed

[9] Ch’en I.L., Tsau J.S., Molkentin J.D., Komatsu M., Hedrick S.M. Mechanisms of necroptosis in T cells. J Exp Med. 2011;208:633–641. doi: 10.1084/jem.20110251. - DOI - PMC - PubMed

[10] Ch’en I.L., Tsau J.S., Molkentin J.D., Komatsu M., Hedrick S.M. Mechanisms of necroptosis in T cells. J Exp Med. 2011;208:633–641. doi: 10.1084/jem.20110251. - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

New components of the necroptotic pathway

Affiliation

New components of the necroptotic pathway

Authors

Affiliation

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Research Materials

Miscellaneous

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Research Materials

Miscellaneous