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Randomized Controlled Trial
. 2012 Nov 7;53(12):7539-45.
doi: 10.1167/iovs.12-10285.

Axial elongation following cataract surgery during the first year of life in the infant Aphakia Treatment Study

Scott R Lambert  1 , Michael J Lynn, Lindreth G DuBois, George A Cotsonis, E Eugenie Hartmann, M Edward Wilson; Infant Aphakia Treatment Study Groups
Collaborators, Affiliations
Randomized Controlled Trial

Axial elongation following cataract surgery during the first year of life in the infant Aphakia Treatment Study

Scott R Lambert et al. Invest Ophthalmol Vis Sci. .

Abstract

Purpose: To compare ocular axial elongation in infants after unilateral cataract surgery corrected with a contact lens (CL) or primary intraocular lens (IOL) implantation.

Methods: Baseline axial length (AL) was measured at the time of cataract surgery (1-6 months) and at age 1 year. AL at baseline and age 1 year and the change in length/mo were analyzed in relation to treatment modality, cataractous versus fellow eye, and age at surgery using linear mixed models.

Results: Mean baseline AL did not differ between the CL and IOL groups for either cataractous or fellow eyes. Eyes with cataracts were shorter than fellow eyes by an average of 0.6 mm (95% confidence interval [CI], 0.4-0.8 mm; P < 0.0001). For the operated eyes, the mean change in AL/mo was smaller in the CL group (0.17 mm/mo) than in the IOL group (0.24 mm/mo) (P = 0.0006) and was independent of age at surgery (P = 0.19). In contrast, the change in AL/mo for fellow eyes decreased with older age at surgery (P < 0.0001). At age 1 year, operated eyes treated with a CL were 0.6 mm shorter on average than operated eyes treated with an IOL (P = 0.009).

Conclusions: At baseline, eyes with cataracts were shorter than fellow eyes. The change in AL/mo was smaller in operated eyes treated with a CL than in operated eyes treated with an IOL, but was not significantly related to age at surgery. (ClinicalTrials.gov number, NCT00212134.).

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Conflict of interest statement

Disclosure: S.R. Lambert, None; M.J. Lynn, None; L.G. DuBois, None; G.A. Cotsonis, None; E.E. Hartmann, None; M.E. Wilson, None

Figures

Figure 1.
Figure 1.
Axial length versus age at surgery for the cataractous eyes.
Figure 2.
Figure 2.
Longitudinal changes in axial length for the aphakic and pseudophakic eyes and fellow eyes in the CL and IOL groups.
Figure 3.
Figure 3.
Mean change in axial length per month versus age at surgery according to treatment group (contact lens versus intraocular lens) and eye (operated versus fellow).
Figure 4.
Figure 4.
Mean axial length at 1 year of age for aphakic and pseudophakic eyes as a function of age at the time of cataract surgery.
See this image and copyright information in PMC

References

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