Reduced pupil diameter in volunteers on stable buprenorphine maintenance therapy with telaprevir: a drug-drug interaction involving p-glycoprotein at the blood-brain barrier?
- PMID: 23074230
- PMCID: PMC3486590
- DOI: 10.1128/AAC.01295-12
Reduced pupil diameter in volunteers on stable buprenorphine maintenance therapy with telaprevir: a drug-drug interaction involving p-glycoprotein at the blood-brain barrier?
Comment on
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Effect of telaprevir on the pharmacokinetics of buprenorphine in volunteers on stable buprenorphine/naloxone maintenance therapy.Antimicrob Agents Chemother. 2012 Jul;56(7):3641-7. doi: 10.1128/AAC.00077-12. Epub 2012 May 7. Antimicrob Agents Chemother. 2012. PMID: 22564847 Free PMC article. Clinical Trial.
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- Alhaddad H, et al. Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood-brain barrier in mice. Crit. Care Med., in press - PubMed
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