It's never too early to look: subclinical disease in sarcomeric dilated cardiomyopathy

Editorial

Jil C Tardiff. Circ Cardiovasc Genet. 2012.

. 2012 Oct 1;5(5):483-6.

doi: 10.1161/CIRCGENETICS.112.964817.

No abstract available

Figures

Subtle abnormalities in contractile function are an early manifestation of sarcomere mutations in dilated cardiomyopathy.
Lakdawala NK, Thune JJ, Colan SD, Cirino AL, Farrohi F, Rivero J, McDonough B, Sparks E, Orav EJ, Seidman JG, Seidman CE, Ho CY. Lakdawala NK, et al. Circ Cardiovasc Genet. 2012 Oct 1;5(5):503-10. doi: 10.1161/CIRCGENETICS.112.962761. Epub 2012 Sep 4. Circ Cardiovasc Genet. 2012. PMID: 22949430 Free PMC article.

1. Dellefave L, McNally EM. The genetics of dilated cardiomyopathy. Curr Opin Cardiol. 2010;25:198–204. - PMC - PubMed
1. Kamisago M, Sharma SD, DePalma SR, Solomon S, Sharma P, McDonough B, et al. Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. N Engl J Med. 2000;343:1688–1696. - PubMed
1. Seidman CE, Seidman JG. Identifying sarcomere gene mutations in hypertrophic cardiomyopathy: A personal history. Circ Res. 2011;108:743–750. - PMC - PubMed
1. Van Driest SL, Ackerman MJ, Ommen SR, Shakur R, Will ML, Nishimura RA, et al. Prevalence and severity of “benign” mutations in the beta-myosin heavy chain, cardiac troponin t, and alpha-tropomyosin genes in hypertrophic cardiomyopathy. Circulation. 2002;106:3085–3090. - PubMed
1. Revera M, van der Merwe L, Heradien M, Goosen A, Corfield VA, Brink PA, et al. Long-term follow-up of r403wmyh7 and r92wtnnt2 hcm families: Mutations determine left ventricular dimensions but not wall thickness during disease progression. Cardiovasc J Afr. 2007;18:146–153. - PMC - PubMed